
<p>Two
substances from coffee, working together, may protect against nerve cell damage
and improve response in animal models of Parkinson’s disease and a similar
disease called dementia with Lewy bodies (DLB), according to new research
funded by the National Center for Complementary and Integrative Health. </p>



<p>The study,
conducted by researchers from the Rutgers Robert Wood Johnson Medical School
and cooperating institutions, was published in a recent issue of the
Proceedings of the National Academy of Sciences.</p>
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<figure class="aligncenter"><img src="https://topnaturalremedy.com/wp-content/uploads/2019/07/coffe-1024x576.jpg" alt="" class="wp-image-1838"/></figure></div>


<p>Coffee
consumption is connected with a reduced risk of Parkinson’s disease, and
caffeine is generally thought to be the protective agent. Still, several lines
of evidence imply that other components of coffee may also play a role. </p>



<p>In this
research, two coffee elements, eicosanoyl-5-hydroxytryptamide (EHT) and
caffeine, were evaluated separately and together in mouse models of Parkinson’s
disease and DLB. Both disorders are associated with abnormal deposits of a
protein called alpha-synuclein in the brain.</p>



<p>These
abnormal deposits alter chemicals in the brain, causing changes that impair
movement and thinking. </p>
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<p>When
administered separately, neither EHT nor caffeine manifested benefit. However,
when administered together for six months, the mixture had beneficial results
in the mouse models. The two coffee elements helped keep an enzyme named
protein phosphatase 2A (PP2A), which reduces the accumulation of
alpha-synuclein, in an active form. </p>



<p>Mice that
received the two substances manifested less buildup of alpha-synuclein, less
nerve inflammation, better nerve cell function, and closer-to-normal behavior.</p>



<p>The
researchers who attended the study recorded that coffee is a complex chemical
mixture containing more than a thousand different substances. Thus, additional
elements of coffee may also act a role in protecting against the
transformations that occur in Parkinson’s disease and DLB. </p>



<p>The
researchers also noted that the amounts of specific elements in coffee vary
depending on the conditions of growth and harvesting of the coffee plant and
the ways of roasting the coffee beans and brewing and filtering the beverage.
As more is discovered, it may become possible to optimize the composition of
coffee to enhance its effects.
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<p>(<a href="https://nccih.nih.gov/research/results/spotlight/substances-in-coffee-may-protect-against-parkinsons-disease-and-dementia" target="_blank" rel="noreferrer noopener" aria-label=" (opens in a new tab)">Source</a>)
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